Initial CDI is usually treated by stopping the inciting antibiotic treatment and rehydrating the patient. With more aggressive strains of bacteria or severely ill patients the treatment of CDI ironically involves giving the patient antibiotics such as metronidazole or vancomycin.
Thankfully, C.diff infections usually respond to treatment. However, the infection recurs and symptoms come back in 25-30% of patients. In these patients, further antibiotic treatment gives diminishing rates of cure. After a second recurrence the chance of a further recurrence increases to 60%. This recurrence is thought to occur as a result of the depletion of ‘good bacteria’ in the gut, which allows C.diff to proliferate.
A medical treatment called Faecal Microbiota Transplantation (FMT) has been shown to be the most successful treatment for recurrent C.diff infection, with primary cure rates of between 81-94% reported in medical studies. FMT is thought to be effective as it replenishes the depleted good bacteria in the patient suffering from C.diff infection.